Suzuki T, Mori T, Tsuji M, Misawa M, Nagase H
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Life Sci. 1994;55(17):PL339-44. doi: 10.1016/0024-3205(94)00774-8.
The effects of delta-receptor antagonists on cocaine- and methamphetamine-induced place preferences were examined in rats. Cocaine- and methamphetamine-induced place preferences were significantly attenuated by naltrindole (NTI: a non-selective delta-opioid receptor antagonist). Furthermore, naltriben (NTB: a selective delta 2-opioid receptor antagonist), but not 7-benzylidenenaltrexone (BNTX: a selective delta 1-opioid receptor antagonist), attenuated the cocaine- and methamphetamine-induced place preferences. These results suggest that delta-opioid receptors, particularly delta 2-opioid receptors, may be involved in the reinforcing effects of cocaine and methamphetamine.
在大鼠中研究了δ受体拮抗剂对可卡因和甲基苯丙胺诱导的位置偏爱效应。纳曲吲哚（NTI：一种非选择性δ阿片受体拮抗剂）可显著减弱可卡因和甲基苯丙胺诱导的位置偏爱。此外，纳曲苄（NTB：一种选择性δ2阿片受体拮抗剂）而非7-亚苄基纳曲酮（BNTX：一种选择性δ1阿片受体拮抗剂）可减弱可卡因和甲基苯丙胺诱导的位置偏爱。这些结果表明，δ阿片受体，尤其是δ2阿片受体，可能参与了可卡因和甲基苯丙胺的强化作用。
