Radzikowski C, Szkudlarek J, Czarnomska A, Steuden J, Krajewski L
Arch Immunol Ther Exp (Warsz). 1976;24(5):697-711.
Biological activity of rabbit antimouse lymphocyte sera (ALS) and their IgG fractions was studied. Several ALS and ALG pools were cytotoxic in vitro for normal and leukemic mouse lymphocytes, causing temporary depletion of circulating leukocytes, prolongation of skin allografts, and progressive growth of L-1210/V leukemia transplanted across an H-2 barrier. As a rule, splenomegaly and a significant increase in the number of spleen cells were observed after i.p. injection of ALG. In experiments on the influence of prolonged treatment with ALG on tumor incidence in mice, one ALG pool appeared to be highly and repeatedly leukemogenic. The possible mechanism of leukemia induction by ALG was discussed.
对兔抗小鼠淋巴细胞血清（ALS）及其IgG组分的生物学活性进行了研究。几种ALS和ALG混合液在体外对正常和白血病小鼠淋巴细胞具有细胞毒性，可导致循环白细胞暂时减少、皮肤同种异体移植存活期延长以及H-2屏障下移植的L-1210/V白血病逐渐生长。通常，腹腔注射ALG后可观察到脾肿大和脾细胞数量显著增加。在关于长期用ALG治疗对小鼠肿瘤发生率影响的实验中，一种ALG混合液似乎具有高度且反复的致白血病性。文中讨论了ALG诱导白血病的可能机制。
