Stevens C F, Wang Y
Laboratory for Molecular Neurobiology, Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92110.
Nature. 1994 Oct 20;371(6499):704-7. doi: 10.1038/371704a0.
Synaptic transmission in the hippocampus is rather unreliable, with many presynaptic action potentials failing to release neurotransmitter. How is this unreliability affected by the alterations in synaptic strength seen in long-term potentiation (LTP) and long-term depression (LTD)? We find that LTP increases synaptic reliability, and LTD decreases it, both without a change in the size of those postsynaptic currents that do occur. Thus LTD is a functional inverse of LTP.
海马体中的突触传递相当不可靠，许多突触前动作电位无法释放神经递质。长期增强作用（LTP）和长期抑制作用（LTD）中所见的突触强度变化是如何影响这种不可靠性的呢？我们发现，LTP提高了突触可靠性，而LTD降低了突触可靠性，且二者均未改变确实发生的那些突触后电流的大小。因此，LTD是LTP的功能相反情况。
