Kloppenberg F W, Gips C H
Rijksuniversiteit, International School of Hepatology GISH, Groningen.
Ned Tijdschr Geneeskd. 1994 Sep 17;138(38):1905-8.
To estimate the number of liver transplantations needed in the Netherlands, using death rates of the two periods 1979-1981 and 1989-1991.
Death rates of different liver diseases were divided into: generally accepted indications (transplantable liver diseases, TLD), alcoholic liver cirrhosis, ALC and primary liver cell carcinoma, PLC. The death rates in the two periods, 1979-1981 and 1989-1991, were compared, and the impact of liver transplantation was determined. Subsequently an estimate of the maximum number of patients for liver transplantation in the Netherlands was made, based on death rates.
Mortality of TLD and PLC rose 14% and 7% respectively, while it dropped 13% for ALC. In the period 1989-1991 liver transplantation appeared to have had a quantitative effect on mortality, especially in the youngest age groups. In the age group 0-59 the maximum number of patients for liver transplantation per year was estimated to be 147, nearly 10 per million inhabitants, excluding ALC and PLC.
In the period 1989-1991 21% of deceased TLD patients up to age 60 received liver transplantation in the Netherlands.
利用1979 - 1981年和1989 - 1991年这两个时期的死亡率，估算荷兰所需肝移植的数量。
将不同肝脏疾病的死亡率分为：普遍认可的适应证（可移植性肝脏疾病，TLD）、酒精性肝硬化（ALC）和原发性肝细胞癌（PLC）。比较1979 - 1981年和1989 - 1991年这两个时期的死亡率，并确定肝移植的影响。随后，根据死亡率对荷兰肝移植患者的最大数量进行了估算。
TLD和PLC的死亡率分别上升了14%和7%，而ALC的死亡率下降了13%。在1989 - 1991年期间，肝移植似乎对死亡率产生了定量影响，尤其是在最年轻的年龄组。在0 - 59岁年龄组中，每年肝移植患者的最大数量估计为147例，每百万居民中近10例，不包括ALC和PLC。
在1989 - 1991年期间，荷兰60岁以下已故的TLD患者中有21%接受了肝移植。
