Regeur L, Jensen G B, Pakkenberg H, Evans S M, Pakkenberg B
Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark.
Neurobiol Aging. 1994 May-Jun;15(3):347-52. doi: 10.1016/0197-4580(94)90030-2.
Precise estimates of total neuron numbers in neocortices of 11 women, mean age 82.6 years (range 79-88) with severe senile dementia of the Alzheimer's type (SDAT) were compared with similar estimates in 10 cognitively normal women of comparable mean age (84.1 years; range 74-92). The total mean nerve cell number in the SDAT group was 16.9 x 10(9) with a coefficient of variation (CV = SD/mean) = 0.14, whereas mean total neuron number in the control group was 18.1 x 10(9), CV = 0.18. In a material of this size the reduction of 6% in neocortical cell number in the SDATs is neither statistically nor biologically significant. Nevertheless, all patients with SDAT were severely demented, having a mean score of 5.6 on a 1-7-scale of dementia. This contrasts with the nondemented individuals who had lived an independent life at home until shortly before death. The SDAT patients showed a rather consistent reduction in cortical volume by 14%, an atrophy that was solely due to a reduced cortical thickness. In addition, all had multiple neocortical plaques (Bielschowsky silver stain).
对11名患有阿尔茨海默病型重度老年性痴呆（SDAT）的女性（平均年龄82.6岁，范围79 - 88岁）新皮质中的神经元总数进行精确估计，并与10名平均年龄相当（84.1岁，范围74 - 92岁）的认知正常女性的类似估计值进行比较。SDAT组的神经细胞总数平均为16.9×10⁹，变异系数（CV = SD/平均值）= 0.14，而对照组的神经元总数平均为18.1×10⁹，CV = 0.18。在这样规模的样本中，SDAT患者新皮质细胞数量减少6%，在统计学和生物学上均无显著意义。然而，所有SDAT患者均患有严重痴呆，在1 - 7级痴呆量表上的平均得分为5.6。这与直到临终前不久还能在家中独立生活的非痴呆个体形成对比。SDAT患者的皮质体积一致减少了14%，这种萎缩完全是由于皮质厚度减小所致。此外，所有人都有多个新皮质斑块（ Bielschowsky银染色）。
