豚鼠皮层和连续细胞系中CCKB型受体的3H-CCK-8S结合比较研究
Comparative 3H-CCK-8S binding studies on CCKB-type receptors in guinea-pig cortex and continuous cell lines.
作者信息
Kaufmann R, Schöneberg T, Henklein P, Boomgaarden M, Sohr D, Ott T
机构信息
Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University of Berlin, Germany.
出版信息
Neuropeptides. 1994 Jun;26(6):429-33. doi: 10.1016/0143-4179(94)90029-9.
The present study was undertaken to compare binding characteristics of CCKB-type receptors in guinea-pig cortex, Jurkat T-cells, GH3 cells and C6 cells. The rank order of potency of a variety of CCK agonists and antagonists in inhibiting specific [3H]CCK-8S binding was highly correlated for the 4 CCKB receptor models as demonstrated by a computer-assisted statistical analysis. Taking the ligand binding profiles as the criterion it is concluded that CCKB receptors in guinea-pig cortex, Jurkat T-cells, pituitary GH3 cells and rat glioma C6 cells share identical pharmacological properties.
本研究旨在比较豚鼠皮层、Jurkat T细胞、GH3细胞和C6细胞中CCKB型受体的结合特性。通过计算机辅助统计分析表明，在4种CCKB受体模型中，多种CCK激动剂和拮抗剂抑制特异性[3H]CCK-8S结合的效价顺序高度相关。以配体结合谱为标准得出结论，豚鼠皮层、Jurkat T细胞、垂体GH3细胞和大鼠胶质瘤C6细胞中的CCKB受体具有相同的药理学特性。
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