Smits R C, Emmen H H, Bertelsmann F W, Kulig B M, van Loenen A C, Polman C H
Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
Neurology. 1994 Sep;44(9):1701-5. doi: 10.1212/wnl.44.9.1701.
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
