Caruso A, Ferrazzani S, De Carolis S, Romano D, Mancinelli S, De Carolis M P
Department of Obstetrics and Gynecology, Catholic University, School of Medicine, Rome, Italy.
Minerva Ginecol. 1994 May;46(5):279-84.
Nifedipine was administered to 49 pregnant women with gestational hypertension as first-line therapy, and were longitudinally studied as paired observations for 3 or 10 day intervals of treatment with nifedipine until delivery. All the patients assumed a slow release formulation of nifedipine at the dose of 40-80 mg/24 hr in 2-3 administrations. Blood pressure was taken at least 4 times a day. The patients were divided in two groups: 32 women with non proteinuric gestational hypertension (NPGH) and 17 women with proteinuric preeclampsia (PP). No statistically significant modification of blood pressure was observed in both groups under treatment. However, NPGH showed a trend to reducing, while PP demonstrated a tendency to worsening both systolic and diastolic blood pressures. After treatment with nifedipine the platelet count of both groups was found unchanged. No adverse fetal or newborn effects imputable to the drug were observed. The present study demonstrates that nifedipine alone, at the doses used, is not effective in reducing blood pressure in long-term treatment. However the treatment could concur to avoid sharp and dangerous increases of blood pressure.
硝苯地平被用于49例妊娠高血压孕妇作为一线治疗药物，并在硝苯地平治疗的3天或10天间隔期内进行配对观察的纵向研究，直至分娩。所有患者均采用硝苯地平缓释制剂，剂量为40 - 80毫克/24小时，分2 - 3次给药。每天至少测量4次血压。患者被分为两组：32例无蛋白尿性妊娠高血压（NPGH）妇女和17例蛋白尿性先兆子痫（PP）妇女。治疗期间两组血压均未观察到统计学上的显著变化。然而，NPGH组血压有下降趋势，而PP组收缩压和舒张压均有恶化趋势。硝苯地平治疗后两组血小板计数均未改变。未观察到可归因于该药物的不良胎儿或新生儿影响。本研究表明，单独使用硝苯地平，在所使用的剂量下，长期治疗对降低血压无效。然而，该治疗可能有助于避免血压急剧危险升高。
