Iino M, Mochizuki S, Ozawa S
Department of Physiology, School of Medicine, Gunma University, Japan.
Neurosci Lett. 1994 May 23;173(1-2):14-6. doi: 10.1016/0304-3940(94)90139-2.
Cultured rat hippocampal neurons were classified into three groups on the basis of the functional properties of their AMPA-subtype glutamate receptors. The type I neuron had AMPA receptors with an outwardly rectifying I-V relation and little permeability to Ca2+ whereas the AMPA receptors in the type II neuron were characterized by marked inward rectification and high Ca2+ permeability. In the third type of neuron, the responses of AMPA receptors exhibited intermediate properties in both I-V relation and Ca2+ permeability. We suggest that these intermediate properties in the third type of neuron reflect the coexistence of Ca(2+)-permeant and Ca(2+)-impermeant AMPA receptors.
培养的大鼠海马神经元根据其AMPA亚型谷氨酸受体的功能特性被分为三组。I型神经元具有外向整流的I-V关系且对Ca2+通透性低的AMPA受体，而II型神经元中的AMPA受体的特征是明显的内向整流和高Ca2+通透性。在第三类神经元中，AMPA受体的反应在I-V关系和Ca2+通透性方面均表现出中间特性。我们认为，第三类神经元中的这些中间特性反映了Ca(2+)通透型和Ca(2+)非通透型AMPA受体的共存。
