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[马胃蛋白酶]

[Equine pepsins].

作者信息

Stepanov V M, Lavrenova G I, Rudenskaia G N, Gonchar M V, Lebareva L S

出版信息

Biokhimiia. 1976;41(7):1285-90.

PMID:793642
Abstract

6 forms of pepsin are found in horse gastric juice. Amino acid sequence is determined of N-terminal (most variable) part of polypeptide chain of main pepsin components. Equine pepsines, which have pI 2.1 and 2.3, are found to have identical amino acid sequence at least for 31 amino acid residues. The same sequence is observed in the component with pI 2.6 for 10 first residues. The sequence of equine pepsin with pI 3.2 has 3 substitutions for 33 amino acids, when compared with pepsines having pI 2.1 and 2.3. The forms of equine pepsin studied are more similar than the other isoenzyme pair, human pepsin and gastricsin.

摘要

在马的胃液中发现了6种胃蛋白酶形式。确定了主要胃蛋白酶成分多肽链N端(变化最大)部分的氨基酸序列。发现等电点为2.1和2.3的马胃蛋白酶,至少在31个氨基酸残基上具有相同的氨基酸序列。在等电点为2.6的成分中,前10个残基观察到相同的序列。与等电点为2.1和2.3的胃蛋白酶相比,等电点为3.2的马胃蛋白酶序列在33个氨基酸中有3个替换。所研究的马胃蛋白酶形式比另一组同工酶对——人胃蛋白酶和胃泌素更为相似。

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