Laird M R, Faber J J, Binder N D
Department of Pediatrics, Oregon Health Sciences University, Portland 97201-3098.
Pediatr Res. 1994 Jul;36(1 Pt 1):102-10. doi: 10.1203/00006450-199407001-00019.
The relationship between uterine driving pressure and maternal placental blood flow was studied after inflation of an aortic occluder previously placed between the renal and ovarian arteries in 10 conscious pregnant rabbits at 28 +/- 1 (mean +/- SEM) d of a 30- to 31-d gestation to test the hypothesis that there is autoregulation of maternal placental blood flow. After control measurements, the femoral artery pressure was reduced 22 +/- 3% from 83 +/- 5 mm Hg and clamped at 65 +/- 4 mm Hg (p < 0.001) for 54 +/- 4 min by servo control. Carotid artery pressure increased from 86 +/- 5 to 98 +/- 6 mm Hg (p < 0.01). There was no change in cardiac output (839 +/- 78 vs 814 +/- 64 mL/min; NS), upper-body flow (651 +/- 62 vs 671 +/- 55 mL/min; NS), or renal flow (111 +/- 14 vs 104 +/- 8 mL/min; NS). Blood flow to tissues below the occluder decreased from 188 +/- 18 to 143 +/- 14 mL/min for the lower body (p < 0.05), 153 +/- 15 to 116 +/- 11 mL/min for the hindquarters (p < 0.05), and 17.7 +/- 1.9 to 12.9 +/- 1.4 mL/min for 13 pregnant uterine horns (p < 0.05). Placental flow to live fetuses per horn decreased from 13.0 +/- 1.9 to 8.9 +/- 1.2 mL/min (p < 0.01), whereas there was no significant change in myoendometrial flow (4.0 +/- 0.3 vs 3.5 +/- 0.5 mL/min; NS). Uterine oxygen consumption was unchanged (1.15 +/- 0.16 vs 1.06 +/- 0.13 mL/min; NS).(ABSTRACT TRUNCATED AT 250 WORDS)
在30至31天妊娠期的28±1（均值±标准误）天时，对10只清醒的妊娠兔进行实验，这些兔子先前在肾动脉和卵巢动脉之间放置了主动脉阻断器，充气后研究子宫驱动压力与母体胎盘血流量之间的关系，以检验母体胎盘血流量存在自动调节这一假设。在进行对照测量后，通过伺服控制将股动脉压力从83±5毫米汞柱降低22±3%，并钳制在65±4毫米汞柱（p<0.001），持续54±4分钟。颈动脉压力从86±5毫米汞柱升至98±6毫米汞柱（p<0.01）。心输出量（839±78对814±64毫升/分钟；无显著性差异）、上身血流量（651±62对671±55毫升/分钟；无显著性差异）或肾血流量（111±14对104±8毫升/分钟；无显著性差异）均无变化。阻断器下方组织的血流量，下半身从188±18降至143±14毫升/分钟（p<0.05），后肢从153±15降至116±11毫升/分钟（p<0.05），13个妊娠子宫角从17.7±1.9降至12.9±1.4毫升/分钟（p<0.05）。每个子宫角向存活胎儿的胎盘血流量从13.0±1.9降至8.9±1.2毫升/分钟（p<0.01），而肌层内膜血流量无显著变化（4.0±0.3对3.5±0.5毫升/分钟；无显著性差异）。子宫耗氧量未改变（1.15±0.16对1.06±0.13毫升/分钟；无显著性差异）。（摘要截断于250字）
