小鼠对DNA免疫反应的特征II. B细胞和T细胞的参与

Features of the immune response to DNA in mice II. Participation of B and T cells.

作者信息

Fournié G J, Lambert P H, Bankhurst A D, Miescher P A

出版信息

Clin Exp Immunol. 1976 Oct;26(1):52-6.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540821/

Abstract

The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nude BALB/c mice. Reconstitution experiments performed in low responder DBA/mice indicated that the immune response to DNA can be increased after transfer of bone marrow cells from high responder NZB mice, even in the presence of thymocytes from DBA/2 mice. In NZB X NZW mice, a major role of bone marrow cells, with a possible modulation by thymus-derived cells during aging, was observed in the spontaneous development of anti-DNA antibodies.

摘要

利用细胞移植技术，在由不同细胞群体重建的小鼠中，研究了胸腺来源和骨髓来源的淋巴细胞在对DNA免疫反应中的各自作用。在无胸腺裸BALB/c小鼠中进行的实验表明，胸腺来源的细胞在对DNA的免疫反应中具有辅助作用。在低反应性DBA/小鼠中进行的重建实验表明，即使存在来自DBA/2小鼠的胸腺细胞，将高反应性NZB小鼠的骨髓细胞移植后，对DNA的免疫反应也会增强。在NZB×NZW小鼠中，观察到骨髓细胞在抗DNA抗体的自发产生中起主要作用，在衰老过程中可能受到胸腺来源细胞的调节。

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引用本文的文献

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