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小鼠对DNA免疫反应的特征II. B细胞和T细胞的参与

Features of the immune response to DNA in mice II. Participation of B and T cells.

作者信息

Fournié G J, Lambert P H, Bankhurst A D, Miescher P A

出版信息

Clin Exp Immunol. 1976 Oct;26(1):52-6.

PMID:793750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540821/
Abstract

The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nude BALB/c mice. Reconstitution experiments performed in low responder DBA/mice indicated that the immune response to DNA can be increased after transfer of bone marrow cells from high responder NZB mice, even in the presence of thymocytes from DBA/2 mice. In NZB X NZW mice, a major role of bone marrow cells, with a possible modulation by thymus-derived cells during aging, was observed in the spontaneous development of anti-DNA antibodies.

摘要

利用细胞移植技术，在由不同细胞群体重建的小鼠中，研究了胸腺来源和骨髓来源的淋巴细胞在对DNA免疫反应中的各自作用。在无胸腺裸BALB/c小鼠中进行的实验表明，胸腺来源的细胞在对DNA的免疫反应中具有辅助作用。在低反应性DBA/小鼠中进行的重建实验表明，即使存在来自DBA/2小鼠的胸腺细胞，将高反应性NZB小鼠的骨髓细胞移植后，对DNA的免疫反应也会增强。在NZB×NZW小鼠中，观察到骨髓细胞在抗DNA抗体的自发产生中起主要作用，在衰老过程中可能受到胸腺来源细胞的调节。

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引用本文的文献

1
T cell abnormalities in NZB mice occur independently of autoantibody production.NZB小鼠的T细胞异常独立于自身抗体产生而发生。
J Exp Med. 1981 Feb 1;153(2):221-34. doi: 10.1084/jem.153.2.221.

本文引用的文献

1
Nature and mode of action of antilymphocytic antiserum.抗淋巴细胞抗血清的性质与作用方式。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130-7. doi: 10.1073/pnas.56.4.1130.
2
Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice.新西兰黑鼠及其他小鼠中的天然胸腺细胞毒性自身抗体和反应性抗原。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1412-5. doi: 10.1073/pnas.68.7.1412.
3
Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid.脱氧核糖核酸抗体：一种检测其与脱氧核糖核酸主要相互作用的方法。
Science. 1968 Aug 23;161(3843):806-7. doi: 10.1126/science.161.3843.806.
4
Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity.小鼠自身免疫现象与肾脏疾病。胸腺切除、衰老及免疫能力衰退的作用。
Lab Invest. 1970 Feb;22(2):121-30.
5
Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides.注射细菌脂多糖后循环血液中DNA的释放及抗DNA抗体的诱导。
J Exp Med. 1974 Nov 1;140(5):1189-206. doi: 10.1084/jem.140.5.1189.
6
Spontaneous "autoimmune disease" in nude mice.裸鼠中的自发性“自身免疫性疾病”。
J Immunol. 1974 Aug;113(2):688-97.
7
Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice.NZB小鼠中对胸腺细胞和胸腺依赖性淋巴细胞特异性自身抗体敏感的细胞数量随年龄减少。
Clin Exp Immunol. 1972 Dec;12(4):455-64.
8
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J Immunol. 1974 Nov;113(5):1618-25.
9
Mechanisms of tolerance and autoimmunity.耐受与自身免疫的机制。
Ann Rheum Dis. 1973 Jul;32(4):283-93. doi: 10.1136/ard.32.4.283.
10
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).通过抗原和细菌脂多糖（内毒素）终止小鼠对人γ球蛋白的耐受性。
J Exp Med. 1973 Mar 1;137(3):740-50. doi: 10.1084/jem.137.3.740.

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