Pérez-Cao A, Gil-Loyzaga P, Merchàn-Pérez A, Tamargo J
Department of Morphological Sciences, Medicine School, Complutense University, Madrid, Spain.
Pharmacol Toxicol. 1994 Jun;74(6):321-9. doi: 10.1111/j.1600-0773.1994.tb01367.x.
The protective effect of either oxodipine or nitrendipine (4 mg/kg/twice daily, orally), two dihydropyridines exhibiting calcium channel-blocking properties, against induced infarct-like lesions was examined. Experimental myocardial infarct-like lesions were induced in rats by subcutaneous injection of isoproterenol (0.5 mg/kg). The lesions were mainly located in subendocardial areas of the free wall of the left ventricle, and were intramural at the apex and ventricular septum. Pretreatment with oxodipine significantly reduced the infarct size in the apical and basal myocardium (P < 0.05). Possible explanations for the lack of effect of nitrendipine pretreatment are discussed.
研究了两种具有钙通道阻滞特性的二氢吡啶类药物——奥索地平或尼群地平（4毫克/千克/每日两次，口服）对诱导性梗死样病变的保护作用。通过皮下注射异丙肾上腺素（0.5毫克/千克）在大鼠中诱导实验性心肌梗死样病变。病变主要位于左心室游离壁的心内膜下区域，在心尖和室间隔处为壁内病变。奥索地平预处理显著减小了心尖和基底心肌的梗死面积（P<0.05）。讨论了尼群地平预处理无效的可能原因。
