简短通讯：甲状旁腺激素相关肽不刺激胎盘对磷酸盐的转运。

Short communication: parathyroid hormone-related peptide does not stimulate phosphate placental transport.

作者信息

Barlet J P, Davicco M J, Rouffet J, Coxam V, Lefaivre J

机构信息

INRA Clermont-Theix, France.

出版信息

Placenta. 1994 Jun;15(4):441-4. doi: 10.1016/0143-4004(94)90010-8.

DOI:10.1016/0143-4004(94)90010-8

PMID:7937599

Abstract

It has been demonstrated that parathyroid hormone-related peptide (PTHrP) stimulates calcium (Ca) placental transport. Ca and inorganic phosphorous (P) metabolisms are intimately linked. Thus we have studied the influence of PTHrP on P placental transport in ewes. In our experimental paradigm, synthetic human PTHrP (1-86) fragment intravenously injected in six single chronically catheterized fetuses (3 x 1 micrograms/fetus/day, from day 129 to day 140 of gestation) had no significant effect upon P placental transport which was 131 +/- 6 and 129 +/- 9 mg/kg fetal weight/day in treated and control fetuses, respectively.

摘要

已证实甲状旁腺激素相关肽（PTHrP）可刺激钙（Ca）的胎盘转运。钙和无机磷（P）的代谢密切相关。因此，我们研究了PTHrP对母羊胎盘磷转运的影响。在我们的实验模式中，向6只长期插管的单胎胎儿静脉注射合成人PTHrP（1 - 86）片段（在妊娠第129天至第140天，每天3次，每次1微克/胎儿），对胎盘磷转运没有显著影响，治疗组和对照组胎儿的胎盘磷转运分别为131±6和129±9毫克/千克胎儿体重/天。