年龄、环境因素与药物代谢。

Age, environmental factors and drug metabolism.

作者信息

O'Mahony M S, Woodhouse K W

机构信息

University Department of Geriatric Medicine, Cardiff Royal Infirmary, U.K.

出版信息

Pharmacol Ther. 1994;61(1-2):279-87. doi: 10.1016/0163-7258(94)90066-3.

DOI:10.1016/0163-7258(94)90066-3

PMID:7938174

Abstract

Both ageing and the environment have a significant impact on xenobiotic metabolism. Furthermore, there is some evidence from in vivo studies that the elderly respond to environmental changes to a lesser degree than younger individuals. This article reviews the available evidence and concentrates on possible underlying mechanisms.

摘要

衰老和环境都会对异生物质代谢产生重大影响。此外，体内研究的一些证据表明，老年人对环境变化的反应程度低于年轻人。本文综述了现有证据，并着重探讨了可能的潜在机制。