Ossenkopp K P, Rabi Y J, Eckel L A, Hargreaves E L
Neuroscience Program, University of Western Ontario, London, Canada.
Physiol Behav. 1994 Aug;56(2):319-24. doi: 10.1016/0031-9384(94)90201-1.
The effect of horizontal rotation of male rats (70 rpm) on core temperature and spontaneous motor activity levels was examined. In Experiment 1, subjects were chemically labyrinthectomized (VNX) by intratympanic (IT) injections of sodium arsanilate and control rats (VNS) received IT injections of saline. Half of the rats in each group were subsequently rotated and the other half sham rotated. Measurement of body temperature prior to, immediately after, and 20 min following rotation revealed significant (all p < 0.01) reductions in temperature immediately after treatment, and 20 min later, in VNS rats. Sham-rotated VNS and all VNX rats failed to exhibit any significant changes in temperature following treatment. In Experiment 2, motor activity level was monitored in chemically labyrinthectomized (VNX) and control (VNS) rats prior to, and following, horizontal rotation. The VNS rats exhibited large (all p < 0.01) depressions in measures of horizontal and vertical spontaneous motor activity following rotation treatment, whereas VNX rats exhibited similar levels of activity in the pre- and postrotation period. These experiments show that, as in humans, exposing rats to horizontal rotation results in reduction of body temperature and motor activity, and that these physiological and behavioral changes require a functional vestibular system.
研究了雄性大鼠水平旋转（70转/分钟）对核心体温和自发运动活动水平的影响。在实验1中，通过鼓室内（IT）注射对氨基苯胂酸钠对实验对象进行化学性迷路破坏（VNX），对照大鼠（VNS）接受IT注射生理盐水。随后，每组一半的大鼠进行旋转，另一半进行假旋转。在旋转前、刚结束后以及结束20分钟后测量体温，结果显示，在VNS大鼠中，治疗刚结束时以及20分钟后体温显著降低（所有p<0.01）。假旋转的VNS大鼠和所有VNX大鼠在治疗后体温均未出现任何显著变化。在实验2中，在化学性迷路破坏（VNX）和对照（VNS）大鼠水平旋转前后监测其运动活动水平。旋转治疗后，VNS大鼠在水平和垂直自发运动活动测量中表现出大幅下降（所有p<0.01），而VNX大鼠在旋转前后的活动水平相似。这些实验表明，与人类一样，让大鼠进行水平旋转会导致体温和运动活动降低，并且这些生理和行为变化需要一个功能正常的前庭系统。
