Pindel B, Jarzab J, Sachs K
Katedry i Kliniki Chorób Wewnetrznych i Alergologii Slaskiej Akademii Medycznej, Katowicach.
Przegl Lek. 1994;51(5):206-9.
The pathomechanism of bronchial asthma is not fully explained. The immunologic reactions in the bronchial epithelium may be better understood by an experimental approach in laboratory animals. Ovalbumin induced asthma in guinea pigs is widely accepted as an experimental model of bronchial asthma and was applied in this study. The bronchoconstriction, bronchial hypersensitivity and humoral immune response were measured after bronchial infection (intranasal Pseudomonas aeruginosa application). The increase of the bronchospastic reaction and bronchial hypersensitivity was observed after intranasal Pseudomonas aeruginosa application. Bacterial infection lead to the increase of the circulating immune complexes level and to the decrease of the haemolytic activity of the complement in serum.
支气管哮喘的发病机制尚未完全阐明。通过对实验动物进行实验的方法，或许能更好地理解支气管上皮中的免疫反应。卵清蛋白诱导的豚鼠哮喘被广泛认为是支气管哮喘的实验模型，并应用于本研究。在支气管感染（经鼻应用铜绿假单胞菌）后，测量支气管收缩、支气管高反应性和体液免疫反应。经鼻应用铜绿假单胞菌后，观察到支气管痉挛反应和支气管高反应性增加。细菌感染导致循环免疫复合物水平升高以及血清中补体溶血活性降低。
