Blum H E
Departement für Innere Medizin, Universitätsspital Zürich.
Schweiz Rundsch Med Prax. 1994 Sep 6;83(36):1000-4.
Hepatitis B virus (HBV) mutants and hepatitis C virus (HCV) genotypes have recently been identified in patients with acute and chronic infections. Mutations may be associated with a specific clinical course of infection, e.g. chronic active or fulminant-hepatitis as well as the development of hepatocellular carcinoma (HCC). Further, mutations may affect clearance of HBV or HCV infection and the response to antiviral therapy with alpha-interferon; however, the exact contribution of specific mutations organotypes to the course of HBV or HCV infection remains to be established.
最近在急性和慢性感染患者中发现了乙型肝炎病毒（HBV）突变体和丙型肝炎病毒（HCV）基因型。突变可能与特定的感染临床病程相关，例如慢性活动性肝炎或暴发性肝炎以及肝细胞癌（HCC）的发生。此外，突变可能影响HBV或HCV感染的清除以及对α干扰素抗病毒治疗的反应；然而，特定突变型对HBV或HCV感染病程的确切影响仍有待确定。
