Bruckert E, Dejager S
Unité d'exploration métabolique pour la prévention des maladies cardiovasculaires, hôpital Pitié-Salpêtrière, Paris.
Rev Prat. 1994 Jun 1;44(11):1487-93.
Lipoprotein lipase (LPL), a 55 kDa secretory glycoprotein produced in numerous tissues, is a hydrolytic enzyme, rate-limiting for the removal of lipoprotein TG from the circulation. It is activated by apoprotein CII present on TG-rich lipoproteins. It is involved in lipid transfer between lipoproteins, and plays an important role in the formation of HDL. The fate of LPL-derived lypolysis products differs between tissues: for instance, in adipose tissue, LPL-mediated delivery of free fatty acids is rate-limiting for TG storage, whereas in muscle it provides an alternate source of lipid fuel. LPL is regulated by hormones like insulin and nutrients; its activity depends on the metabolic state of the tissue. It has distinct roles in many normal tissues, such as adipocytes or muscles, as well as an important role in atherogenic dyslipidemia and in metabolic diseases including obesity and hypertriglyceridemia.
脂蛋白脂肪酶（LPL）是一种在多种组织中产生的55 kDa分泌性糖蛋白，是一种水解酶，对从循环中清除脂蛋白甘油三酯（TG）起限速作用。它被富含TG的脂蛋白上存在的载脂蛋白CII激活。它参与脂蛋白之间的脂质转运，并在高密度脂蛋白（HDL）的形成中起重要作用。LPL衍生的脂解产物在不同组织中的命运不同：例如，在脂肪组织中，LPL介导的游离脂肪酸递送是TG储存的限速因素，而在肌肉中，它提供了脂质燃料的替代来源。LPL受胰岛素等激素和营养物质的调节；其活性取决于组织的代谢状态。它在许多正常组织中具有不同的作用，如脂肪细胞或肌肉，以及在致动脉粥样硬化性血脂异常和包括肥胖症和高甘油三酯血症在内的代谢性疾病中起重要作用。
