Dousset B, Houssin D
Clinique chirurgicale, Hôpital Cochin, Paris.
Rev Prat. 1994 Jun 1;44(11):1500-7.
Liver transplantation has become the treatment of many chronic liver diseases, acute hepatic failure and several metabolic diseases in children. Early referral to a transplantation center represents the major condition for its favourable outcome, in order to undertake this complex surgical procedure under the best conditions and to allow a rapid and complete recovery. The increasing shortage of organs leading to graft reduction, graft splitting and living related donation, the feasibility of multiple organ transplantation, the progress of gene therapy, the development of new extra-corporeal liver assist devices and the introduction of the auxiliary partial orthotopic liver transplantation have all contributed to significative changes in the perspectives of pediatric liver transplantation. Furthermore, new immunosuppressors as well as encouraging experimental results on graft tolerance may help in the near future to improve the long-term quality of life of pediatric recipients.
肝移植已成为治疗儿童多种慢性肝病、急性肝衰竭及几种代谢性疾病的方法。尽早转诊至移植中心是取得良好治疗效果的主要条件，以便在最佳条件下进行这一复杂的外科手术，并实现快速且完全的康复。器官日益短缺导致了移植物减少、移植物分割和活体亲属供肝，多器官移植的可行性、基因治疗的进展、新型体外肝辅助装置的研发以及辅助性部分原位肝移植的引入，都促使小儿肝移植前景发生了重大变化。此外，新型免疫抑制剂以及关于移植物耐受性的鼓舞人心的实验结果，可能在不久的将来有助于提高小儿肝移植受者的长期生活质量。
