Barthélémy I, Coustal B, Michelet V, Pinsolle J, Siberchicot F, Caix P, Michelet F X
Services de Chirurgie Maxillo-Faciale, C.H.U. de Bordeaux.
Rev Stomatol Chir Maxillofac. 1994;95(4):302-5.
Head and neck bone sarcomas are very uncommon tumors. Therefore, treatment modalities are not clearly established. The medical record of 12 patients with bone sarcoma of the jaw were reviewed. Six patients with osteosarcoma underwent primary chemotherapy followed by wide surgical resection, radiation therapy or combined radiosurgical treatment. The 2 and 5 years survivals were 66% and 40% respectively. Five patients with chondrosarcoma were treated by wide surgical resection alone or combined with postoperative radiotherapy and possibly chemotherapy. All patients were alive; the mean follow-up was 9 years. One patient had Ewing's tumor. Osteosarcoma and chondrosarcoma in head and neck patients have a high rate of local recurrences. Surgery is the mainstay of treatment. Patients with voluminous tumors and high-grade lesions should receive postoperative radiotherapy. The role of chemotherapy has not been defined.
头颈部骨肉瘤是非常罕见的肿瘤。因此，治疗方式尚未明确确立。回顾了12例颌骨骨肉瘤患者的病历。6例骨肉瘤患者先接受了新辅助化疗，随后进行了广泛的手术切除、放射治疗或联合放射外科治疗。2年和5年生存率分别为66%和40%。5例软骨肉瘤患者仅接受了广泛的手术切除，或联合术后放疗及可能的化疗。所有患者均存活；平均随访时间为9年。1例患者患有尤因肉瘤。头颈部骨肉瘤和软骨肉瘤的局部复发率很高。手术是主要的治疗方法。肿瘤体积大且病变分级高的患者应接受术后放疗。化疗的作用尚未明确。
