Bottecchia D, Fantin G, Gruppo F, Nassuato G
Haemostasis. 1976;5(3):176-88. doi: 10.1159/000214133.
The ionophore for divalent cations, A 23187, induces plate aggregation and clot retraction. Acetylsalicyclic acid has a potentiating effect on the aggregation induced by A 23187 in platelet-rich plasma, while it inhibits the aggregation of washed platelets. Acetylation of plasma proteins could be the reason of the increased platelet aggregation induced by A 23187 in the presence of acetylsalicyclic acid. Platelet aggregation by A 23187 is probably activated by the passage of Ca2+ through the platelet membrane(s); the aggation, clot retraction by A 23187 requires increased availability in the intracellular space of both Ca2+ and Mg2+.
二价阳离子载体A 23187可诱导血小板聚集和血块收缩。乙酰水杨酸对富含血小板血浆中由A 23187诱导的聚集有增强作用，而它抑制洗涤过的血小板的聚集。血浆蛋白的乙酰化可能是在乙酰水杨酸存在的情况下A 23187诱导血小板聚集增加的原因。A 23187引起的血小板聚集可能是由Ca2+穿过血小板膜而激活的；A 23187引起的聚集、血块收缩需要细胞内空间中Ca2+和Mg2+的可用性增加。
