Chromosomal assignments of mouse genes for connexin 50 and connexin 33 by somatic cell hybridization.

The 12 known connexin genes coding for the subunit proteins of the gap junction channels and related in nucleotide sequence are widely dispersed in the mouse genome. By using a series of mouse X Chinese hamster somatic cell hybrids and molecular probes of murine connexin genes, we have assigned the connexin 50 gene to mouse chromosome 3. The connexin 33 gene has been mapped to the X chromosome, thus confirming the previous chromosomal assignment of this gene based on interspecific back-cross mapping.