正电子发射断层扫描研究多中心胶质瘤：一例报告。

Multicentric glioma studied with positron emission tomography: a case report.

作者信息

Sato K, Kameyama M, Ishiwata K, Kayama T, Yoshimoto T, Ito M

机构信息

Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Surg Neurol. 1994 Jul;42(1):14-8. doi: 10.1016/0090-3019(94)90243-7.

DOI:10.1016/0090-3019(94)90243-7

PMID:7940089

Abstract

Positron emission tomography (PET) studies of a multicentric glioma case were undertaken using 11C-methionine (Met) and 18F-fluorodeoxyuridine (FUdR). Met-PET revealed high accumulating lesion in both the left and right hemispheres, whereas in the FUdR-PET, the lesion on the right showed marked accumulation, but not that on the left. For both foci, the histologic diagnoses were anaplastic astrocytoma, but the lesion on the right showed higher density of undifferentiated tumor cells than that on the left. PET studies using Met and FUdR are effective in delineating the proliferative potential of glioma cells, which otherwise cannot be determined by histopathologic studies.

摘要

采用¹¹C-蛋氨酸（Met）和¹⁸F-氟脱氧尿苷（FUdR）对一例多中心胶质瘤病例进行了正电子发射断层扫描（PET）研究。Met-PET显示左右半球均有高聚集性病变，而在FUdR-PET中，右侧病变有明显聚集，左侧则无。两个病灶的组织学诊断均为间变性星形细胞瘤，但右侧病灶的未分化肿瘤细胞密度高于左侧。使用Met和FUdR的PET研究在描绘胶质瘤细胞的增殖潜能方面是有效的，否则无法通过组织病理学研究来确定。