Ogawa T, Shishido F, Kanno I, Inugami A, Fujita H, Murakami M, Shimosegawa E, Ito H, Hatazawa J, Okudera T
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita, Japan.
Radiology. 1993 Jan;186(1):45-53. doi: 10.1148/radiology.186.1.8380108.
The authors examined 50 patients with cerebral glioma with use of positron emission tomography (PET) and L-[methyl]-[11C]methionine to assess the grade of malignancy and the extent of cerebral glioma. Carbon-11 methionine was highly accumulated in the lesion in 31 of 32 patients with high-grade glioma and 11 of 18 patients with low-grade glioma. The rate of uptake of C-11 methionine in high-grade glioma was significantly higher than in low-grade glioma (P < .001). However, in individual cases it was difficult to evaluate the grade of malignancy only from the degree of C-11 methionine accumulation. In most cases, the area of increased accumulation of C-11 methionine did not correspond to the abnormalities seen at computed tomography (CT). Surgical intervention confirmed that methionine PET delineated the extent of cerebral glioma more clearly than did CT. The authors concluded that methionine PET has greater utility in assessing the extent rather than the grade of malignancy of cerebral glioma.
作者使用正电子发射断层扫描（PET）和L-[甲基]-[¹¹C]蛋氨酸对50例脑胶质瘤患者进行了检查，以评估脑胶质瘤的恶性程度和范围。在32例高级别胶质瘤患者中的31例以及18例低级别胶质瘤患者中的11例中，¹¹C蛋氨酸在病变部位高度聚集。高级别胶质瘤中¹¹C蛋氨酸的摄取率显著高于低级别胶质瘤（P <.001）。然而，在个别病例中，仅根据¹¹C蛋氨酸的聚集程度很难评估恶性程度。在大多数情况下，¹¹C蛋氨酸聚集增加的区域与计算机断层扫描（CT）显示的异常并不对应。手术干预证实，蛋氨酸PET比CT更能清晰地勾勒出脑胶质瘤的范围。作者得出结论，蛋氨酸PET在评估脑胶质瘤的范围而非恶性程度方面具有更大的效用。
