Reilly J M, Rubin B G, Thompson R W, Allen B T, Anderson C B, Sicard G A
Department of Surgery, Washington University School of Medicine, St. Louis, Mo.
Surgery. 1994 Oct;116(4):784-90; discussion 790-1.
The efficacy of direct aortorenal bypass and renal artery endarterectomy are well established. The purpose of this study is to define better the results of extraanatomic renal revascularization procedures.
From April 1987 to March 1993, 124 patients underwent renal artery revascularization. Forty-eight (39%) of them (33 women, 15 men; average age, 65.9 years) underwent 49 extraanatomic renal artery bypasses. Preoperative risk factors included smoking in 30 patients (61%), history of myocardial infarction in 14 (29%), diabetes mellitus in 11 (22%), congestive heart failure in nine (18%), chronic obstructive pulmonary disease in 11 (22%), and stroke in six (12%). The average creatinine level was 2.3 mg/dl. The average number of antihypertensive medications was 2.4. Thirty iliorenal, 10 gastroduodenal-renal, seven hepatorenal, and two splenorenal bypasses were performed together with 10 contralateral nephrectomies.
Six major postoperative complications occurred. There were no deaths. Forty-one (85%) of patients had improvement or cure of their hypertension. Seven (15%) of patients failed to respond to treatment, and three required subsequent nephrectomy. After operation the average creatinine level was 1.7 mg/dl and the average number of medications was 1.7. Mean follow-up period has been 23.2 months (range, 1 to 79 months).
Extraanatomic bypass proved to be efficacious in treating hypertension and preserving renal function and has an acceptable rate of morbidity and mortality. We conclude that these procedures are an acceptable alternative to direct aortorenal artery revascularization.
直接主动脉肾动脉搭桥术和肾动脉内膜切除术的疗效已得到充分证实。本研究的目的是更好地明确解剖外肾血管重建手术的结果。
1987年4月至1993年3月,124例患者接受了肾动脉血管重建术。其中48例(39%)(33例女性,15例男性;平均年龄65.9岁)接受了49次解剖外肾动脉搭桥术。术前危险因素包括30例(61%)吸烟、14例(29%)有心肌梗死病史、11例(22%)患有糖尿病、9例(18%)患有充血性心力衰竭、11例(22%)患有慢性阻塞性肺疾病以及6例(12%)有中风病史。平均肌酐水平为2.3mg/dl。平均抗高血压药物数量为2.4种。共进行了30例髂肾、10例胃十二指肠肾、7例肝肾和2例脾肾搭桥术,同时进行了10例对侧肾切除术。
发生了6例主要术后并发症。无死亡病例。41例(85%)患者的高血压得到改善或治愈。7例(15%)患者对治疗无反应,3例需要随后进行肾切除术。术后平均肌酐水平为1.7mg/dl,平均药物数量为1.7种。平均随访期为23.2个月(范围1至79个月)。
解剖外搭桥术被证明在治疗高血压和保留肾功能方面有效,且发病率和死亡率可接受。我们得出结论,这些手术是直接主动脉肾动脉血管重建术的可接受替代方案。