Petersen L R, Lackritz E, Lewis W F, Smith D S, Herrera G, Raimondi V, Aberle-Grasse J, Dodd R Y
Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Transfusion. 1994 Oct;34(10):865-9. doi: 10.1046/j.1537-2995.1994.341095026971.x.
The confidential unit exclusion (CUE) option is intended to reduce human immunodeficiency virus (HIV) transmission by excluding donors newly infected with HIV who have not yet developed HIV antibody (window-period donors); however, its efficacy in excluding window-period donors has not been evaluated.
The use of the CUE option was studied among the donors of 3.7 million units at 18 American Red Cross blood services regions during 1991 and 1992 and among 322 previously HIV-1-seronegative donors who subsequently donated a seropositive unit between 1987 and 1990 at 40 United States blood centers. These seroconverting donors had previously been shown to be highly likely to donate during their window period.
On the basis of data from these two populations, it was estimated that only 3 to 5 percent of units donated by window-period donors were not transfused because of the CUE option, that 0.4 percent of all donations were from donors who confidentially excluded their blood from transfusion, and that donors who confidentially excluded their blood were 21 times more likely to be HIV antibody-positive than donors who did not use the CUE option. It is estimated that, if all US blood centers used the CUE option, a total of 2 to 17 otherwise acceptable units donated by window-period donors would not be transfused annually.
Although donors who confidentially exclude their blood from transfusion are 21 times more likely to have HIV antibody, the rarity of window-period donors and the infrequency of confidential exclusion by window-period donors cause the CUE option to have minimal impact on transfusion safety.
保密单位排除（CUE）选项旨在通过排除新感染人类免疫缺陷病毒（HIV）但尚未产生HIV抗体的献血者（窗口期献血者）来减少HIV传播；然而，其在排除窗口期献血者方面的效果尚未得到评估。
1991年和1992年期间，在美国红十字会18个血液服务区域的370万单位献血者中研究了CUE选项的使用情况，以及在40个美国血液中心1987年至1990年期间322名先前HIV-1血清学阴性、随后捐献了血清学阳性单位的献血者中研究了该选项的使用情况。这些血清转化献血者此前已被证明在窗口期很有可能献血。
根据这两个人群的数据估计，由于CUE选项，窗口期献血者捐献的单位中只有3%至5%未被输注，所有捐献中0.4%来自保密排除其血液用于输注的献血者，且保密排除其血液的献血者HIV抗体呈阳性的可能性是未使用CUE选项的献血者的21倍。据估计，如果美国所有血液中心都使用CUE选项，每年将有2至17个原本可接受的由窗口期献血者捐献的单位不会被输注。
尽管保密排除其血液用于输注的献血者HIV抗体呈阳性的可能性是其他献血者的21倍，但窗口期献血者罕见，且窗口期献血者保密排除的情况很少，导致CUE选项对输血安全的影响微乎其微。
