Smikle M F, James O B
Department of Microbiology, U.W.I., Jamaica.
West Indian Med J. 1994 Jun;43(2):59-62.
Various serological techniques were used to investigate the prevalence and distribution of autoantibodies in healthy Jamaicans and patients with autoimmune and non-autoimmune disease. Low concentrations of autoantibodies were found in healthy Jamaicans, including thyroid (1.5%), gastric parietal cell (1.4%) and smooth muscle (11.3%). There was no significant age or sex predominance in the distribution of autoantibodies in the healthy population though autoimmune disease was more prevalent in females. Serological overlaps occurred but the comparative distributions and concentrations of autoantibodies in patients with autoimmune disease and non-autoimmune disease, and healthy subjects indicate that currently available methods of autoantibody determination may be used successfully in diagnosis in Jamaica. Failure to detect circulating pancreatic islet cell antibodies in insulin-dependent diabetic patients as well as in healthy Jamaicans questions the pathogenicity of these antibodies and diminishes their diagnostic usefulness in this population.
采用多种血清学技术研究了牙买加健康人群、自身免疫性疾病患者和非自身免疫性疾病患者自身抗体的流行情况和分布。在牙买加健康人群中发现了低浓度的自身抗体，包括甲状腺自身抗体（1.5%）、胃壁细胞自身抗体（1.4%）和平滑肌自身抗体（11.3%）。尽管自身免疫性疾病在女性中更为普遍，但在健康人群中自身抗体的分布没有明显的年龄或性别优势。存在血清学重叠现象，但自身免疫性疾病患者、非自身免疫性疾病患者和健康受试者中自身抗体的比较分布和浓度表明，目前可用的自身抗体检测方法在牙买加的诊断中可能会成功应用。在胰岛素依赖型糖尿病患者以及牙买加健康人群中均未检测到循环胰岛细胞抗体，这对这些抗体的致病性提出了质疑，并降低了它们在该人群中的诊断价值。
