Kupietz R, Faber J, Heidegger H
Frauenklinik, Klinikums Bamberg.
Zentralbl Gynakol. 1994;116(8):468-73.
100 women participated in an open randomised study. 50 of them received 0.5 mg PGE2 in 2.5 ml Triacetin gel (Prepidil) intracervically in the morning (6.00 a.m.) and 50 at night (10.00 p.m.). The success rate was 74% (37 of 50) in the treatment group of the night compared with 52 (26 of 50) in the group of morning labor induction. A second dose after 8 hours was necessary in 26% (13 of 50) in the night group and in 48% (24 of 50) of the morning labor induction. Labor induction failed completely in 32% of the morning and in 12% of the night group. The induction time for contractions was 2 hours shorter after night labor induction, in primiparae the duration of first stage was 2 hours shorter but in multiparae there was no difference between the groups. There was also no difference in intrapartum and postpartum complications between the groups. In conclusion the induction of labor with intracervical PGE2 at night seems to be more effective without increasing the rate of complications.
100名女性参与了一项开放性随机研究。其中50人于早晨（上午6点）宫颈内给予2.5毫升三醋精凝胶（普贝生）中含有的0.5毫克前列腺素E2，另外50人于晚上（晚上10点）给药。晚上治疗组的成功率为74%（50例中的37例），而早晨引产组为52%（50例中的26例）。晚上组26%（50例中的13例）和早晨引产组48%（50例中的24例）在8小时后需要给予第二剂。早晨组32%和晚上组12%引产完全失败。晚上引产后宫缩诱导时间缩短2小时，初产妇第一产程持续时间缩短2小时，但经产妇组间无差异。两组间产时和产后并发症也无差异。总之，晚上宫颈内给予前列腺素E2引产似乎更有效，且不增加并发症发生率。
