Totolian N A, Griazeva I V, Klimovich V B, Skoromets A A
Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(2):49-53.
The serum and liquor of 70 patients with multiple sclerosis (MS), 54 patients with other neurological diseases and 20 controls were examined for free light chains (FLC) of immunoglobulins type chi and lambda. The findings were compared to blood-brain barrier competence, liquor pleocytosis, IgG intrathecal synthesis 86% MS patients exhibited high levels of liquor chi-type FLC which appeared early in the disease course irrespectively of MS phase and pattern. Simultaneous high content of lambda-type FLC was reported in 52% of the cases. Patients in need of differential diagnosis were characterized by normal or reduced (in spinocerebellar ataxia) concentrations of FLC except for the conditions with impaired blood-brain barrier.
对70例多发性硬化症（MS）患者、54例其他神经系统疾病患者和20例对照者的血清和脑脊液进行免疫球蛋白κ型和λ型游离轻链（FLC）检测。将结果与血脑屏障功能、脑脊液细胞增多、IgG鞘内合成情况进行比较。86%的MS患者脑脊液κ型FLC水平较高，在疾病进程早期出现，与MS的阶段和模式无关。52%的病例同时报告λ型FLC含量较高。除血脑屏障受损的情况外，需要进行鉴别诊断的患者FLC浓度正常或降低（在脊髓小脑共济失调患者中）。
