人类细小病毒B19引发的缺铁性贫血再生障碍危象

Human parvovirus B19-induced aplastic crisis in iron deficiency anemia.

作者信息

Kudoh T, Yoto Y, Suzuki N, Oda T, Katoh S, Chiba S, Matsunaga Y

机构信息

Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.

出版信息

Acta Paediatr Jpn. 1994 Aug;36(4):448-9. doi: 10.1111/j.1442-200x.1994.tb03221.x.

DOI:10.1111/j.1442-200x.1994.tb03221.x

PMID:7942015

Abstract

Human parvovirus B19 (HPVB19) infects and replicates in erythroid progenitor cells. Its specific cytotoxic effect on these cells results in aplastic crises in patients with congenital hemolytic anemias. Aplastic crisis due to HPVB19 infection in a healthy girl revealed occult iron deficiency anemia. The condition is characterized by a high serum iron level in the aplastic phase and rapid recovery after administration of iron. Temporary HPVB19-induced red blood cell aplasia could occur in patients with other anemias, particularly those with non-inherited form of hemolysis.

摘要

人细小病毒B19（HPVB19）在红系祖细胞中感染并复制。它对这些细胞的特异性细胞毒性作用导致先天性溶血性贫血患者发生再生障碍危象。一名健康女孩因HPVB19感染引发的再生障碍危象揭示了隐匿性缺铁性贫血。该病症的特征是再生障碍期血清铁水平升高，补铁后迅速恢复。其他贫血患者，尤其是非遗传性溶血形式的患者，可能会出现HPVB19诱导的暂时性红细胞再生障碍。