Genazzani A D, Petraglia F, Gastaldi M, Volpogni C, Surico N, Genazzani A R
Department of Obstetrics and Gynecology, University of Modena, Italy.
Gynecol Endocrinol. 1994 Jun;8(2):95-100. doi: 10.3109/09513599409058029.
Amenorrhea associated with weight loss is characterized by several neuroendocrine aberrations. The aim of the present study was to define the characteristics of episodic secretion of prolactin in women with weight loss-related amenorrhea. To evaluate whether hypoestrogenism was responsible for the changes in prolactin secretion in amenorrheic women, the pulsatile secretory pattern was also studied during hormone replacement therapy (HRT). Fifteen patients were studied by blood sampling every 10 min for 8 h. Four normally cycling women were studied as a reference group, during both the midfollicular and midluteal phases. Mean plasma prolactin levels and pulse amplitude were lower in amenorrheic patients than in controls. The prolactin pulse frequency was higher than that in controls during the follicular phase, but lower than controls during the luteal phase of the menstrual cycle. During HRT, mean plasma prolactin levels significantly increased, pulse frequency decreased and pulse amplitude significantly increased both during estradiol and estradiol plus medroxyprogesterone acetate administration. In conclusion, in amenorrhea associated with weight loss the chronobiological organization of prolactin secretion is deranged, both as a result of a neuroendocrine alteration and as a result of low plasma levels of gonadal steroids.
与体重减轻相关的闭经具有多种神经内分泌异常特征。本研究的目的是确定体重减轻相关闭经女性中催乳素的间歇性分泌特征。为评估低雌激素血症是否导致闭经女性催乳素分泌变化，在激素替代疗法（HRT）期间也研究了脉冲分泌模式。对15名患者每10分钟采血一次，共采集8小时。4名正常月经周期女性作为参照组，在卵泡中期和黄体中期进行研究。闭经患者的平均血浆催乳素水平和脉冲幅度低于对照组。在月经周期的卵泡期，催乳素脉冲频率高于对照组，但在黄体期低于对照组。在HRT期间，在给予雌二醇以及雌二醇加醋酸甲羟孕酮期间，平均血浆催乳素水平显著升高，脉冲频率降低，脉冲幅度显著增加。总之，在与体重减轻相关的闭经中，催乳素分泌的时间生物学组织紊乱，这既是神经内分泌改变的结果，也是性腺类固醇血浆水平低的结果。
