Farman C, Chen Z P, Branston N, Symon L
Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England, U.K.
Acta Neurochir (Wien). 1994;127(3-4):210-4. doi: 10.1007/BF01808768.
The direct cortical response (DCR) and associated local cerebral blood flow was recorded from the primate cerebral cortex during a period of focal ischaemia induced by middle cerebral artery occlusion (MCAO). The DCR was lost when local blood flow fell below 20 ml/100 g/min but began to recover as collateral flow increased. Hypercapnia demonstrated a loss of local vascular reactivity following MCAO, but isovolaemic haemodilution still proved effective in increasing blood flow to these areas. The reduction in blood oxygen content induced by haemodilution did not impair cerebral function but the reduction in whole blood viscosity did exacerbate cerebral susceptibility to hypercapnia-induced intra-cerebral steal.
在大脑中动脉闭塞（MCAO）诱导的局灶性缺血期间，记录了灵长类动物大脑皮质的直接皮质反应（DCR）及相关的局部脑血流量。当局部血流降至20 ml/100 g/min以下时，DCR消失，但随着侧支血流增加开始恢复。高碳酸血症表明MCAO后局部血管反应性丧失，但等容血液稀释仍被证明可有效增加这些区域的血流量。血液稀释引起的血氧含量降低并未损害脑功能，但全血粘度降低确实加剧了大脑对高碳酸血症诱导的脑内盗血的易感性。
