Angulo J C, López J I, Sanchez-Chapado M
Facultad de Medicina, Universidad del País Vasco (UPV/EHU), Bilbao Vizcaya.
Actas Urol Esp. 1994 Jun;18(6):651-5.
Muscle-invading urothelial carcinoma of the bladder, stage B of the Jewett-Marshall Scale (T2-T3a/pN0), treated effectively with radical cystectomy, is known to be a highly curable disease. But certain difficulties arise when it comes to apply the traditional morphological factor to the prognosis of this population, partly due to their relative small numbers and the lack of prospective studies on the subject. Apart from the presence or absence of lymph invasion, it is unclear whether the prognostic factors of poor evolution in tumours are also valid in more invasive lesions. This paper presents the cytogenetic study conducted in 7 patients with Stage B urothelial carcinoma in cystectomy portions. All of them showed favourable evolution except for one case with associated profusion of marker chromosomes and tetraploidy. As it has already been shown in Stage T1 vesical carcinoma, this association almost certainly carries a major predictive value of poor prognosis in the muscle-invading localized disease.
膀胱肌层浸润性尿路上皮癌，Jewett-Marshall分期为B期（T2-T3a/pN0），行根治性膀胱切除术后可有效治疗，已知这是一种治愈率很高的疾病。但是，当将传统形态学因素应用于该人群的预后评估时会出现某些困难，部分原因是该人群数量相对较少且缺乏关于该主题的前瞻性研究。除了有无淋巴结浸润外，尚不清楚肿瘤进展不良的预后因素在更具侵袭性的病变中是否也有效。本文介绍了对7例B期尿路上皮癌患者膀胱切除标本进行的细胞遗传学研究。除1例伴有大量标记染色体和四倍体的病例外，所有患者均显示预后良好。正如T1期膀胱癌中已经显示的那样，这种关联几乎肯定对肌层浸润性局限性疾病的预后不良具有主要预测价值。
