Yamakawa N, Tanaka T, Hijikata S, Konoeda Y, Usui M
Department of Ophthalmology, Tokyo Medical College, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Aug;98(8):760-4.
S-antigen or interphotoreceptor retinoid-binding protein (IRBP), when injected with Freund's complete adjuvant into mice, does not easily cause experimental autoimmune uveoretinitis (EAU). In this report, we describe the results of injecting IRBP with Freund's complete adjuvant, together with the intraperitoneal administration of Bordetella pertussis, into several types of congenic mice (B10, B10A, B10BR, B10D2). These congenic mice, of C57BL/10 (B10) origin, differ at the H-2 locus on chromosome 17. We were able to produce EAU in 38.5% of B10A mice, and 12.5% of B10BR mice, confirming that EAU can develop in these mice that carry the k genotype at the K, I-A, and I-E regions of the major histocompatibility complex (MHC) H-2 locus. We believe that the k genotype of the K, I-A, and I-E regions is important as a factor in the pathogenesis of EAU in congenic B10 mice.
S抗原或光感受器间类视黄醇结合蛋白（IRBP）与弗氏完全佐剂一起注射到小鼠体内时，不容易引发实验性自身免疫性葡萄膜视网膜炎（EAU）。在本报告中，我们描述了将IRBP与弗氏完全佐剂一起注射，并腹腔注射百日咳博德特氏菌到几种同基因小鼠（B10、B10A、B10BR、B10D2）体内的结果。这些起源于C57BL/10（B10）的同基因小鼠在17号染色体上的H-2位点存在差异。我们在38.5%的B10A小鼠和12.5%的B10BR小鼠中成功诱导出EAU，证实携带主要组织相容性复合体（MHC）H-2位点K、I-A和I-E区域k基因型的这些小鼠能够发生EAU。我们认为，K、I-A和I-E区域的k基因型作为同基因B10小鼠EAU发病机制中的一个因素很重要。
