Ferraris A M, Rolfo M, Mangerini R, Gaetani G F
Division of Hematological Oncology, Instituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Am J Hematol. 1994 Nov;47(3):237-8. doi: 10.1002/ajh.2830470318.
Following reports on a variety of interactions between glutathione (GSH) concentration and clinical parameters in solid tumors, a study was undertaken in order to determine the GSH intracellular content of chronic lymphocytic leukemia (CLL) lymphocytes. The results from a group of 16 patients consecutively studied indicate tht B-CLL cells have twice as much GSH as lymphocytes from normal subjects, suggesting that this measurement may be helpful in the understanding of the metabolic mechanism of the disease and the rationale of therapy.
在有关于实体瘤中谷胱甘肽（GSH）浓度与临床参数之间各种相互作用的报道之后，开展了一项研究以确定慢性淋巴细胞白血病（CLL）淋巴细胞的细胞内GSH含量。对连续研究的16名患者组的结果表明，B - CLL细胞的GSH含量是正常受试者淋巴细胞的两倍，这表明该测量可能有助于理解该疾病的代谢机制和治疗原理。
