利用选定的同胞对进行数量性状基因座区间定位的功效。
The power of interval mapping of quantitative trait loci, using selected sib pairs.
作者信息
Cardon L R, Fulker D W
机构信息
Department of Mathematics, Stanford University, CA 94305.
出版信息
Am J Hum Genet. 1994 Oct;55(4):825-33.
Abstract
The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.
摘要
富尔克和卡登用于分析数量性状基因座（QTL）的区间作图程序被扩展，以应用于同胞对的选择样本。已知当使用单个标记时，对同胞对进行表型选择会显著提高检验效能，而当使用区间作图方法时，检验效能会进一步提高。在粗略图谱中，联合方法的最大优势最为明显，在这种情况下，在大小合理的同胞样本中，相隔较宽（相距40 - 60厘摩）的标记就能检测到遗传力相对适中（15% - 20%）的QTL。在选择样本和未选择样本中，区间作图都能提供有关QTL位置的有用信息。
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