Mollejo M, Menárguez J, Cristóbal E, Algara P, Sánchez-Díaz E, Fraga M, Piris M A
Department of Pathology, Virgen de la Salud Hospital, Toledo, Spain.
Am J Surg Pathol. 1994 Nov;18(11):1131-9.
Neoplastic monocytoid B-cells (MBCs) are present in different amounts in several types of non-Hodgkin's lymphomas (NHLs), including monocytoid B-cell lymphoma (MBCL), splenic marginal zone lymphoma (SMZL), mucosa-associated lymphoid tissue (MALT) low-grade B-cell lymphomas, and follicular centroblastic-centrocytic (CB-CC) lymphomas. In an attempt to clarify the relationships between different groups of tumors with a significant monocytoid component, we studied six primary lymph node MBCL, three SMZL, seven MALT lymphomas, and four CB-CC with monocytoid differentiation. Their clinical, morphological, immunohistochemical and molecular features were compared. The results show wide overlapping between MALT and MBCL in terms of morphology, immunophenotype, and molecular features. Follicular colonization was a characteristic finding in both groups. Some MBCL revealed mucosal involvement during the course of the disease, suggesting a possible MALT origin. Our data support the suggestion that the use of the term MBCL should be discontinued in cases with mucosal involvement, as they are probably examples of lymph node involvement brought about by MALT lymphomas. Although SMZL have some overlapping features with MBCL and MALT lymphomas, some of the clinical and morphological specific findings justify their distinction from the other groups. The CB-CCs with monocytoid differentiation frequently harbored t(14;18), lacking any significant differentiating features from conventional follicular CB-CC lymphomas. Additional studies are needed to define the molecular features of MBCL and other marginal zone tumors.
肿瘤性单核样B细胞（MBCs）在几种非霍奇金淋巴瘤（NHLs）中含量各异，包括单核样B细胞淋巴瘤（MBCL）、脾边缘区淋巴瘤（SMZL）、黏膜相关淋巴组织（MALT）低度B细胞淋巴瘤以及滤泡中心母细胞-中心细胞（CB-CC）淋巴瘤。为了阐明具有显著单核样成分的不同肿瘤组之间的关系，我们研究了6例原发性淋巴结MBCL、3例SMZL、7例MALT淋巴瘤以及4例具有单核样分化的CB-CC。比较了它们的临床、形态学、免疫组化和分子特征。结果显示，MALT和MBCL在形态学、免疫表型和分子特征方面存在广泛重叠。滤泡定植是两组的特征性表现。部分MBCL在疾病过程中出现黏膜受累，提示可能起源于MALT。我们的数据支持以下建议：对于有黏膜受累的病例，应停止使用MBCL这一术语，因为它们可能是MALT淋巴瘤导致的淋巴结受累的例子。尽管SMZL与MBCL和MALT淋巴瘤有一些重叠特征，但一些临床和形态学的特异性表现证明它们与其他组不同。具有单核样分化的CB-CC经常存在t(14;18)，与传统滤泡性CB-CC淋巴瘤相比缺乏任何显著的鉴别特征。需要进一步研究来确定MBCL和其他边缘区肿瘤的分子特征。
