Franssila K O, Jaser N, Sivula A
Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
APMIS. 1993 Aug;101(8):631-41.
All cases of gastrointestinal (GI) non-Hodgkin's lymphoma diagnosed in Finland between 1972 and 1977 were histologically reexamined and immunostained in order to study the value of histological classification. One hundred and eleven cases were found. The crude annual incidence was 0.51/10(5) and the age-adjusted (world standard population) incidence 0.23/10(5). The male-to-female ratio of age-adjusted incidence rates was 2.7. The most common histological type was large B-cell lymphoma comprising 61% of all classifiable cases. Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma comprised 12%, centrocytic lymphoma 9%, peripheral T-cell lymphoma 9%, Burkitt's lymphoma 7% and large-cell anaplastic lymphoma 3% of the total. In the jejunum, almost one half of the cases were T-cell lymphomas and there were no lymphomas with definite MALT features. Gastric lymphomas had higher survival rates than intestinal lymphomas, B-cell lymphomas slightly higher survival rates than T-cell lymphomas, and low-grade MALT lymphomas higher survival rates than other B-cell lymphomas. The other types of lymphomas differed only slightly from each other in prognosis. The histological grade according to the Working Formulation correlated with survival rates, but a great majority of cases were classified as intermediate grade. Classification of GI lymphomas into the types mentioned above appears to correlate with several clinical and pathological parameters.
为研究组织学分类的价值，对1972年至1977年期间在芬兰诊断出的所有胃肠道非霍奇金淋巴瘤病例进行了组织学复查和免疫染色。共发现111例。粗年发病率为0.51/10万，年龄调整后（世界标准人口）发病率为0.23/10万。年龄调整发病率的男女比例为2.7。最常见的组织学类型是大B细胞淋巴瘤，占所有可分类病例的61%。低级别黏膜相关淋巴组织（MALT）淋巴瘤占总数的12%，中心细胞淋巴瘤占9%，外周T细胞淋巴瘤占9%，伯基特淋巴瘤占7%，大细胞间变性淋巴瘤占3%。在空肠中，近一半病例为T细胞淋巴瘤，且无具有明确MALT特征的淋巴瘤。胃淋巴瘤的生存率高于肠道淋巴瘤，B细胞淋巴瘤的生存率略高于T细胞淋巴瘤，低级别MALT淋巴瘤的生存率高于其他B细胞淋巴瘤。其他类型的淋巴瘤在预后方面彼此差异仅轻微。根据工作方案确定的组织学分级与生存率相关，但绝大多数病例被归类为中级。将胃肠道淋巴瘤分类为上述类型似乎与若干临床和病理参数相关。
