Tope W D, Sangueza O P
Department of Dermatology, Oregon Health Sciences University, Portland.
Am J Dermatopathol. 1994 Jun;16(3):307-10.
Rhinophyma may present with either of two distinct histopathologic appearances. The most common shows histopathologic features of rosacea. The second pattern shows telangiectasia, diffuse dermal fibrosis with abundant mucin, and a virtual absence of pilosebaceous structures. These histopathologic features of the lesser-known fibrous variant of rhinophyma mimic those of fibrous papule of the nose. We report an unusual case that histopathologically resembled the second variant. Immunohistochemically, the dermal fibroblasts in this case showed intense staining with Factor XIIIa in a pattern similar to that demonstrated in fibrous papules. S-100 protein failed to stain these dermal fibroblasts. The presence of Factor XIIIa+ dermal fibroblasts may portend the evolution of fibrosis in rosacea and other inflammatory dermatoses.
酒渣鼻性痤疮可能呈现出两种不同的组织病理学表现中的任何一种。最常见的表现出酒渣鼻的组织病理学特征。第二种模式表现为毛细血管扩张、伴有大量黏蛋白的弥漫性真皮纤维化，以及几乎没有皮脂腺结构。酒渣鼻性痤疮鲜为人知的纤维变体的这些组织病理学特征类似于鼻部纤维丘疹的特征。我们报告了一例组织病理学上类似于第二种变体的不寻常病例。免疫组织化学显示，该病例中的真皮成纤维细胞对ⅩⅢa因子呈强染色，其模式与纤维丘疹中显示的模式相似。S-100蛋白未能使这些真皮成纤维细胞染色。ⅩⅢa因子阳性的真皮成纤维细胞的存在可能预示着酒渣鼻和其他炎症性皮肤病中纤维化的演变。
