Buniatian A A, Trekova N A, Flerov E V, Shitikov I I, Poplavskiĭ I V
Anesteziol Reanimatol. 1993 May-Jun(3):11-4.
The effect of a novel ultrashort acting beta-adrenoblocker esmolol on systemic and pulmonary hemodynamics has been studied intraoperatively in 81 cardiosurgical patients. All the patients were operated under ataralgesia. Esmolol is an effective controlled agent for the treatment and prevention of supraventricular tachycardia and hyperdynamic reaction developing in cardiothoracic patients during anesthesia and surgery. Bolus injection of 100 mg esmolol exerts a negative chronotropic effect with maximum heart rate decrease by 23.3% by minute 5 and a gradual attenuation of the effect by minute 20. A parallel drop in the cardiac output by 18.5% is caused predominantly by a decrease in the heart rate and accounts for BP reduction. The above esmolol dose does not have a considerable effect on pulmonary hemodynamics and does not enhance intrapulmonary venous shunting.
在81例心脏外科手术患者术中研究了新型超短效β-肾上腺素能阻滞剂艾司洛尔对全身和肺血流动力学的影响。所有患者均在无痛觉状态下接受手术。艾司洛尔是治疗和预防心胸外科患者在麻醉和手术期间发生室上性心动过速和高动力反应的有效可控药物。静脉推注100mg艾司洛尔产生负性变时作用，至第5分钟时心率最大降幅为23.3%，至第20分钟时作用逐渐减弱。心输出量平行下降18.5%，主要是由心率降低引起的，这也是血压降低的原因。上述剂量的艾司洛尔对肺血流动力学没有显著影响，也不会增加肺内静脉分流。
