Dill H, Altstidl R, Regenfus M, Lehmkuhl H, Bachmann K
Medizinische Klinik II mit Poliklinik, University Erlangen-Nuremberg, Germany.
Angiology. 1994 Oct;45(10):877-82. doi: 10.1177/000331979404501007.
In addition to further studies using Doppler catheters to assess blood flow velocity during coronary angioplasty this study intends to evaluate the functional significance of coronary stenoses and to estimate their hemodynamic relevance prior to and after percutaneous transluminal coronary angioplasty (PTCA). Diameters of coronary artery stenoses were quantified by means of the cardiovascular angiographic analysis system (CAAS) both prior to and following successful PTCA in 37 patients. During coronary artery angioplasty a 12 M:Hz 0.018-in. Doppler-tipped guidewire was used to measure prestenotic and poststenotic parameters of coronary artery flow velocity both prior to and following PTCA. The minimal stenosis diameter was raised from 1.01 +/- 0.58 to 1.76 +/- 0.73 mm (P < 0.0001), the percent diameter stenosis decreased from 63 +/- 11 to 35 +/- 6% (P < 0.0001). Prestenotic average (APV) and maximum peak velocity (MPV), peak velocity integral (PVI), average systolic (ASPV) and diastolic (ADPV) peak velocity, systolic (SPVI) and diastolic (DPVI) peak velocity integral, and diastolic/systolic velocity ratio showed--in contrast to further studies--a considerably significant difference (P < 0.05), whereas poststenotic Doppler data (APV, MPV, PVI, ASPV, DSPV, SPVI, DPVI, DSVR) differed highly significantly (P < 0.0001) prior to and following PTCA. Prestenotic and poststenotic measurements of coronary artery flow velocity differed significantly before and after PTCA and offer the potential for estimating both the hemodynamic relevance of coronary artery stenoses and success of PTCA.
