Kojima T, Ono A, Aoki T, Kameda-Hayashi N, Kobayashi Y
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Ann Allergy. 1994 Oct;73(4):351-5.
Circulating intercellular adhesion molecule-1 (ICAM-1) levels were measured in 48 patients with atopic dermatitis (mild in 29, moderate in 13, and severe in 6) and in 32 controls. Circulating ICAM-1 levels gradually increased with the severity of atopic dermatitis (216 +/- 68 in control, 323 +/- 66 in mild, 376 +/- 92 in moderate, and 555 +/- 93 ng/mL in severe atopic dermatitis, respectively). A significant correlation was observed between serum ICAM-1 and eosinophilic cationic protein levels in patients with atopic dermatitis (r = .71, P < .01). Although a significant positive correlation was observed between serum eosinophilic cationic protein levels and peripheral eosinophil counts (r = .63, P < .01), only a weak correlation was observed between serum ICAM-1 levels and peripheral eosinophil counts (r = .35, P < .05). Changes in serum ICAM-1 levels in ten patients treated with ketotifen for 3 months were also demonstrated. A close correlation was observed between serum ICAM-1 levels and the disease severity (r = .76, P < .01). From these results, we speculate that serum ICAM-1 level may reflect the extent of inflamed tissue in atopic dermatitis.
在48例特应性皮炎患者（轻度29例、中度13例、重度6例）和32名对照者中检测了循环细胞间黏附分子-1（ICAM-1）水平。循环ICAM-1水平随特应性皮炎严重程度逐渐升高（对照组为216±68，轻度特应性皮炎为323±66，中度为376±92，重度特应性皮炎为555±93 ng/mL）。在特应性皮炎患者中，血清ICAM-1与嗜酸性阳离子蛋白水平之间存在显著相关性（r = 0.71，P < 0.01）。虽然血清嗜酸性阳离子蛋白水平与外周嗜酸性粒细胞计数之间存在显著正相关（r = 0.63，P < 0.01），但血清ICAM-1水平与外周嗜酸性粒细胞计数之间仅存在弱相关性（r = 0.35，P < 0.05）。还展示了10例接受酮替芬治疗3个月的患者血清ICAM-1水平的变化。血清ICAM-1水平与疾病严重程度之间存在密切相关性（r = 0.76，P < 0.01）。根据这些结果，我们推测血清ICAM-1水平可能反映特应性皮炎中炎症组织的程度。
