The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.

作者信息

Gliemann J, Nykjaer A, Petersen C M, Jørgensen K E, Nielsen M, Andreasen P A, Christensen E I, Lookene A, Olivecrona G, Moestrup S K

机构信息

Department of Medical Biochemistry, University of Aarhus, Denmark.

出版信息

Ann N Y Acad Sci. 1994 Sep 10;737:20-38. doi: 10.1111/j.1749-6632.1994.tb44299.x.

DOI:10.1111/j.1749-6632.1994.tb44299.x

PMID:7944146

Abstract

摘要

相似文献

The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.

Ann N Y Acad Sci. 1994 Sep 10;737:20-38. doi: 10.1111/j.1749-6632.1994.tb44299.x.

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.参与尿激酶-1型抑制剂复合物和尿激酶原与内吞性α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合的区域。尿激酶受体保护尿激酶原不与内吞性受体结合的证据。

J Biol Chem. 1994 Oct 14;269(41):25668-76.

LRP and the receptor-mediated endocytosis of plasminogen activators.低密度脂蛋白受体相关蛋白与纤溶酶原激活剂的受体介导内吞作用

Ann N Y Acad Sci. 1994 Sep 10;737:70-87. doi: 10.1111/j.1749-6632.1994.tb44302.x.

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.低密度脂蛋白受体相关蛋白和gp330结合相似的配体，包括纤溶酶原激活物-抑制剂复合物和乳铁蛋白，后者是乳糜微粒残粒清除的抑制剂。

J Biol Chem. 1992 Dec 25;267(36):26172-80.

Binding of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex to the endocytosis receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor.尿激酶型纤溶酶原激活物-纤溶酶原激活物抑制剂-1复合物与内吞作用受体α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白及极低密度脂蛋白受体的结合涉及抑制剂中的碱性残基。

Biochem J. 1998 Jan 1;329 ( Pt 1)(Pt 1):55-63. doi: 10.1042/bj3290055.

Specificity of serine proteinase/serpin complex binding to very-low-density lipoprotein receptor and alpha2-macroglobulin receptor/low-density-lipoprotein-receptor-related protein.丝氨酸蛋白酶/丝氨酸蛋白酶抑制剂复合物与极低密度脂蛋白受体及α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合的特异性

Eur J Biochem. 1997 Sep 1;248(2):270-81. doi: 10.1111/j.1432-1033.1997.00270.x.

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase.α2-巨球蛋白受体/低密度脂蛋白受体相关蛋白结合脂蛋白脂肪酶以及与该脂肪酶相关的β-迁移极低密度脂蛋白。

J Biol Chem. 1993 Jul 15;268(20):15048-55.

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats.α2-巨球蛋白-蛋白酶复合物、1型纤溶酶原激活物抑制剂-纤溶酶原激活物复合物以及受体相关蛋白与α2-巨球蛋白受体的一个区域结合，该区域含有一簇八个补体样重复序列。

J Biol Chem. 1993 Jun 25;268(18):13691-6.

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of alpha 2-macroglobulin receptor and urokinase receptor expression.佛波酯在不同细胞系中对尿激酶-1型抑制剂复合物内吞作用的差异调节与α2-巨球蛋白受体及尿激酶受体表达的差异调节相关。

Mol Cell Endocrinol. 1995 Apr 1;109(2):209-17. doi: 10.1016/0303-7207(95)03504-z.

Cellular catabolism of normal very low density lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is induced by the C-terminal domain of lipoprotein lipase.正常极低密度脂蛋白通过低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体的细胞分解代谢由脂蛋白脂肪酶的C末端结构域诱导。

J Biol Chem. 1994 Jul 8;269(27):18001-6.

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Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains.硬骨鱼类尿激酶型纤溶酶原激活物样蛋白酶缺乏真正的受体结合表皮生长因子样结构域。

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Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly.低密度脂蛋白受体相关蛋白是一种钙网蛋白共受体，可发出粘着斑解体的信号。

J Cell Biol. 2003 Jun 23;161(6):1179-89. doi: 10.1083/jcb.200302069.

Tethering and tickling: a new role for the phosphatidylserine receptor.拴系与挠痒：磷脂酰丝氨酸受体的新作用。

J Cell Biol. 2001 Nov 12;155(4):501-4. doi: 10.1083/jcb.200110066.

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells.细胞表面钙网蛋白和CD91的C1q及甘露糖结合凝集素结合启动巨胞饮作用和凋亡细胞摄取。

J Exp Med. 2001 Sep 17;194(6):781-95. doi: 10.1084/jem.194.6.781.

Structure of a rat α₁-macroglobulin receptor-binding domain dimer.大鼠α₁-巨球蛋白受体结合结构域二聚体的结构

Protein Sci. 2000 Oct;9(10):1889-97. doi: 10.1110/ps.9.10.1889.

Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein.低密度脂蛋白受体相关蛋白（LRP）与一种GTP结合蛋白相互作用。

Biochem J. 1998 Dec 1;336 ( Pt 2)(Pt 2):381-6. doi: 10.1042/bj3360381.

Ligand-binding domains in vitellogenin receptors and other LDL-receptor family members share a common ancestral ordering of cysteine-rich repeats.卵黄蛋白原受体及其他低密度脂蛋白受体家族成员中的配体结合结构域，在富含半胱氨酸的重复序列上具有共同的祖先排序。

J Mol Evol. 1998 Apr;46(4):476-87. doi: 10.1007/pl00006328.

Biochem J. 1998 Jan 1;329 ( Pt 1)(Pt 1):55-63. doi: 10.1042/bj3290055.

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.低密度脂蛋白受体相关蛋白在一种中枢神经系统来源的神经元细胞系中介导载脂蛋白E依赖的神经突生长。

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9480-4. doi: 10.1073/pnas.92.21.9480.

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