Goyffon M
Centre de Recherches du Service de Santé des Armées, La Tronche.
Ann Pharm Fr. 1994;52(2):99-109.
Research into venoms have been extensively developed during the last years, and some groups of venomous animals seldom studied have been recently the subject of new important results, such as the Cones (Gasteropodes, Molluscs) and Spiders, in the venom of which new types of neurotoxic molecules have been described. Concerning the most studied groups, new toxic molecules have been identified in snake (Dendroaspis sp., Atractaspis sp.) and scorpion venoms. The scorpion venoms contain a large variety of toxins acting on various ionic channels, Na+, K+, Ca++ or Cl-. Many structural relations between venomous toxins (Cones and Najas) or between toxins and physiological molecules (sarafotoxins and endothelins, scorpion toxins and Arthropod defensins) have been described and raise important phylogenetic problems which might be also the starting point of new domains of applied research.
在过去几年中,对毒液的研究得到了广泛发展,一些此前很少被研究的有毒动物群体最近成为了新的重要研究成果的主题,比如芋螺(腹足纲、软体动物)和蜘蛛,在它们的毒液中发现了新型神经毒性分子。关于研究最多的动物群体,在蛇(树眼镜蛇属、穴蝰属)和蝎子的毒液中也鉴定出了新的有毒分子。蝎子毒液含有多种作用于各种离子通道(钠离子、钾离子、钙离子或氯离子通道)的毒素。已经描述了有毒毒素之间(芋螺毒素和眼镜蛇毒素)或毒素与生理分子之间(萨拉毒素和内皮素、蝎子毒素和节肢动物防御素)的许多结构关系,这些关系引发了重要的系统发育问题,而这些问题也可能成为新的应用研究领域的起点。