Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors. - Suppr | 超能文献

Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors.

作者信息

Sofia R D

出版信息

Ann Neurol. 1994 Oct;36(4):677-8. doi: 10.1002/ana.410360423.

DOI:10.1002/ana.410360423

Abstract

摘要

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Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors.

Ann Neurol. 1994 Oct;36(4):677-8. doi: 10.1002/ana.410360423.

2

Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors.抗惊厥药非氨酯的作用机制：对N-甲基-D-天冬氨酸受体和γ-氨基丁酸A受体的相反作用

Ann Neurol. 1994 Feb;35(2):229-34. doi: 10.1002/ana.410350216.

3

Felbamate block of the N-methyl-D-aspartate receptor.非氨酯对N-甲基-D-天冬氨酸受体的阻断作用

J Pharmacol Exp Ther. 1995 May;273(2):878-86.

4

Felbamate, a novel antiepileptic drug, reverses N-methyl-D-aspartate/glycine-stimulated increases in intracellular Ca2+ concentration.

Eur J Pharmacol. 1995 Apr 28;289(2):229-33. doi: 10.1016/0922-4106(95)90099-3.

5

Re: Mazarati et al. "...clinically available [antiepileptic drug] with a moderate affinity for the glycine site of the N-methyl-D-aspartate (NMDA) receptor".回复：马扎拉蒂等人。“……临床上可用的[抗癫痫药物]，对N-甲基-D-天冬氨酸（NMDA）受体的甘氨酸位点具有中等亲和力”。

Epilepsia. 2000 Jul;41(7):918-9. doi: 10.1111/j.1528-1157.2000.tb00265.x.

6

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.由士的宁不敏感型甘氨酸受体介导的非氨酯抗惊厥和神经保护作用的证据。

J Pharmacol Exp Ther. 1993 Mar;264(3):1248-52.

7

Felbamate antagonizes isoniazid- and FG 7142-induced reduction of GABAA receptor function in mouse brain.非氨酯可拮抗异烟肼和FG 7142诱导的小鼠脑内GABAA受体功能降低。

Eur J Pharmacol. 1994 Nov 24;265(3):185-8. doi: 10.1016/0014-2999(94)90431-6.

8

Neurochemical studies with the anticonvulsant felbamate in mouse brain.

Pharmacol Res. 1999 Sep;40(3):257-61. doi: 10.1006/phrs.1999.0511.

9

Effect of anticonvulsant felbamate on GABAA receptor system.抗惊厥药非氨酯对GABAA受体系统的作用。

Epilepsia. 1991 May-Jun;32(3):389-91. doi: 10.1111/j.1528-1157.1991.tb04667.x.

10

Felbamate, an anti-convulsive drug, has anti-parkinsonian potential in rats.非氨酯，一种抗惊厥药物，在大鼠中具有抗帕金森病的潜力。

Neurosci Lett. 1994 Sep 26;179(1-2):115-8. doi: 10.1016/0304-3940(94)90948-2.

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Antagonism of convulsions but failure to enhance GABA(A) receptor function by felbamate in mice tolerant to diazepam.非氨酯对苯二氮䓬耐受小鼠惊厥的拮抗作用及对GABA(A)受体功能增强的失败。

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