局部应用CTC-96会加速感染棉尾兔乳头瘤病毒的兔子的疣生长。

Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus.

作者信息

Ostrow R S, Coughlin S, McGlennen R C, Liu Z, Zelterman D, Faras A J

机构信息

Institute of Human Genetics, Medical School, University of Minnesota, Minneapolis 55455.

出版信息

Antiviral Res. 1994 May;24(1):27-35. doi: 10.1016/0166-3542(94)90049-3.

DOI:10.1016/0166-3542(94)90049-3

PMID:7944311

Abstract

CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.

摘要

CTC-96是一种含钴复合物，在我们的棉尾兔乳头瘤病毒（CRPV）-兔模型系统中，作为一种假定的局部治疗剂，用于治疗乳头瘤病毒诱导的肿瘤。在用CRPV对家兔进行实验性感染后，每天两次将CTC-96应用于感染部位，每周5天，共8周。将两种浓度水平的水性CTC-96与接受安慰剂对照治疗的动物进行比较。随着CTC-96剂量的增加，我们观察到每只动物的八个感染部位出现肿瘤的时间更早、肿瘤更大且更频繁。