Lunn G, Sansone E B
Program Resources, Inc./DynCorp, Environmental Control and Research Program, NCI-Frederick Cancer Research and Development Center, MD 21702-1201.
Appl Biochem Biotechnol. 1994 Aug;48(2):57-9. doi: 10.1007/BF02796162.
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, N alpha-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability of these compounds decreased as the pH increased.
在缓冲液、二甲基亚砜或储备溶液中的五种酶抑制剂（苯甲基磺酰氟、4-脒基苯甲磺酰氟、4-(2-氨基乙基)苯磺酰氟、Nα-对甲苯磺酰-L-赖氨酸氯甲基酮和N-对甲苯磺酰-L-苯丙氨酸氯甲基酮）通过加入1M氢氧化钠被完全降解，最终反应混合物无致突变性。这些化合物的稳定性随pH升高而降低。
