[区域化疗研究：肝动脉灌注治疗转移性肝肿瘤]

[A study of regional chemotherapy: hepatic arterial infusion for metastatic liver tumors].

作者信息

Takahashi T, Misuta K, Masui H, Ike H, Ohki S, Shimada H

机构信息

Second Dept. of Surgery, Yokohama City University.

出版信息

Gan To Kagaku Ryoho. 1994 Sep;21(13):2155-7.

PMID:7944427

Abstract

This study was designed to evaluate whether intraarterial and intra-portal infusion chemotherapy was effective in 57 patients with liver metastases from colorectal cancer and 10 from gastric cancer. Arterial infusion was effective to prevent recurrence in the remnant liver after resection of liver metastases from colorectal cancer. On the other hand, intra-portal infusion was not effective to prevent recurrence. In the patients with unresectable metastases, arterial infusion was also effective for the response rate, which was 75% (with intra-portal infusion) and 27 % (arterial infusion only), respectively. However, arterial infusion had no effect in patients with metastases from gastric cancer. As a result, arterial infusion was effective to prevent recurrence after resection of metastases, and to increase the survival rate in patients with unresectable metastases from colorectal cancer.

摘要

本研究旨在评估动脉内和门静脉内灌注化疗对57例结直肠癌肝转移患者和10例胃癌肝转移患者是否有效。动脉灌注对预防结直肠癌肝转移切除术后残肝复发有效。另一方面，门静脉内灌注对预防复发无效。在无法切除转移灶的患者中，动脉灌注对缓解率也有效，门静脉内灌注的缓解率为75%，单纯动脉灌注的缓解率为27%。然而，动脉灌注对胃癌转移患者无效。结果，动脉灌注对预防转移灶切除术后复发有效，并提高了无法切除的结直肠癌转移患者的生存率。