Akaike M, Takemiya S, Sugimasa Y, Okamoto T
Dept. of Surgery 4, Kanagawa Cancer Center.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1563-6.
We evaluated the effect of hepatic arterial infusion chemotherapy (HAI) and intraportal infusion chemotherapy (IPI) for liver metastasis of colorectal cancer. Since 1980, 89 patients with colorectal cancer showed liver metastasis. Seven of these cases had undergone curative resection of colon tumor and hepatectomy (5 cases with HAI). Eleven cases had undergone colon tumor resection and HAI. Among the former, 3 cases with HAI are alive, and the postoperative survival rate after 2 years improved among the latter. Curative removal was carried out in 567 patients in the same period. Recurrence of liver metastasis was observed in 30 cases, in 13 cases of which hepatectomy with HAI was performed, with HAI only in another 9 cases. The three-year survival rate among the former was 41.1% and the one-year survival rate of the latter was 16.2%. From 1986 to 1988, we performed IPI in 24 cases of colorectal cancer to prevent liver metastasis. They had undergone curative resection. Recurrence of liver metastasis was observed in one case (4.2%), which was less than in the control group (9.3%). It is concluded that HAI and IPI are effective treatment for liver metastasis in colorectal cancer.
我们评估了肝动脉灌注化疗（HAI）和门静脉内灌注化疗（IPI）对结直肠癌肝转移的疗效。自1980年以来，89例结直肠癌患者出现肝转移。其中7例接受了结肠肿瘤根治性切除和肝切除术（5例行HAI）。11例接受了结肠肿瘤切除和HAI。在前者中，3例行HAI的患者存活，后者术后2年生存率有所提高。同期567例患者进行了根治性切除。观察到30例肝转移复发，其中13例进行了HAI肝切除术，另外9例仅行HAI。前者的三年生存率为41.1%，后者的一年生存率为16.2%。1986年至1988年，我们对24例结直肠癌患者进行了IPI以预防肝转移。他们均接受了根治性切除。观察到1例（4.2%）出现肝转移复发，低于对照组（9.3%）。结论是HAI和IPI是治疗结直肠癌肝转移的有效方法。
